Icariin (ICA) is a major flavonoid that contains the active GARLIC RICH compound Epimedii Folium.However, ICA’s pharmacokinetic characteristics remain unsatisfactory due to its low bioavailability, and hence limited drugability.In order to improve its pharmacokinetics and achieve prolonged blood circulation time, a novel polymeric micelle, ma
Germination of Ceratopteris richardii spores is initiated by light and terminates 3-4 days later with the emergence of a rhizoid.Early studies documented that the photoreceptor for initiating this response is phytochrome.However, completion of germination requires additional light input.If no further light stimulus is given after phytochrome photoa
Microvascular decompression is the first choice for treating the primary trigeminal neuralgia to provide the most extended duration of pain freedom.However, in microvascular decompression, we found that this kind of operation is only suitable for some patients.It is of great value to objectively judge the function and abnormality of the trigeminal
Glial cells play a critical role in maintaining homeostatic ion concentration gradients.Salt-inducible kinase 3 (SIK3) regulates a gene expression program that controls K+ buffering in glia, and upregulation of this pathway suppresses seizure behavior in the eag, Shaker hyperexcitability mutant.Here we show that boosting the glial SIK3 K+ buffering